Uttam S, Stern AM, Sevinsky C, Furman S, Pullara F, Spagnolo D, Nguyen L, Gough A, Ginty F, Taylor DL., Chennubhotla CS Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks. Nature Communications. 2020 Jul 14; 11(1):3515; PMID: 32665557 PMCID: PMC7360741;DOI: 10.1038/s41467-020-17083-x.
Jane EP, Premkumar DR, Thambireddy S, Golbourn B, Agnihotri S, Bertrand KC, Mack SC, Myers MI, Chattopadhyay A, Taylor DL, Schurdak ME, Stern AM, Pollack IF. Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance. Mol Cancer Res. 2020 Apr 1;. doi: 10.1158/1541-7786.MCR-19-0669. [Epub ahead of print] PubMed PMID: 32238439.
Albert Gough, Alejandro Soto-Gutierrez, Lawrence Vernetti, Mo R. Ebrahimkhani, Andrew M. Stern, D. Lansing Taylor. Human Liver Biomimetic Microphysiology Systems in Therapeutic Discovery, Development and Precision Medicine. Nature Reviews, 2021 April; 18(4):252-268 doi: 10.1038/s41575-020-00386-1. Epub 2020 Dec 17.
Argemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, Cabezas J, Lozano JJ, Van Booven D, Bell A, Cao S, Vernetti LA, Arab JP, Ventura-Cots M, Edmunds LR, Fondevilla C, Stärkel P, Dubuquoy L, Louvet A, Odena G, Gomez JL, Aragon T, Altamirano J, Caballeria J, Jurczak MJ, Taylor DL, Berasain C, Wahlestedt C, Monga SP, Morgan MY, Sancho-Bru P, Mathurin P, Furuya S, Lackner C, Rusyn I, Shah VH, Thursz MR, Mann J, Avila MA, Bataller R. Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Nat Commun. 2019 Jul 16;10(1):3126. PubMed PMID: 31311938; PubMed Central PMCID: PMC6635373.
Abecassis I, Sedgewick AJ, Romkes M, Buch S, Nukui T, Kapetanaki MG, Vogt A, Kirkwood JM, Benos PV, Tawbi H. PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy. Sci Rep. 2019;9(1):3309. PubMed PMID: 30824778; PMCID: PMC6397203.
Kho DH, Uddin MH, Chatterjee M, Vogt A, Raz A, Wu GS. GP78 Cooperates with Dual-Specificity Phosphatase 1 To Stimulate Epidermal Growth Factor Receptor-Mediated Extracellular Signal-Regulated Kinase Signaling. Mol Cell Biol. 2019;39(11). PubMed PMID: 31061093; PMCID: PMC6517599.
Nmezi B, Vollmer LL, Shun TY, Gough A, Rolyan H, Liu F, Jia Y, Padiath QS, Vogt A. Development and Optimization of a High-Content Analysis Platform to Identify Suppressors of Lamin B1 Overexpression as a Therapeutic Strategy for Autosomal Dominant Leukodystrophy. SLAS Discov. 2020:2472555220915821. PubMed PMID: 32349647.
Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23. Yablonska S, Ganesan V, Ferrando LM, Kim J, Pyzel A, Baranova OV, Khattar NK, Larkin TM, Baranov SV, Chen N, Strohlein CE, Stevens DA, Wang X, Chang YF, Schurdak ME, Carlisle DL, Minden JS and Friedlander RM (2019) Proceedings of the National Academy of Sciences of the United States of America;116(33):16593-602. Epub 2019/07/28. doi: 10.1073/pnas.1904101116. PubMed PMID: 31346086.
Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology. Taylor DL, Gough A, Schurdak ME, Vernetti L, Chennubhotla CS, Lefever D, Pei F, Faeder JR, Lezon TR, Stern AM and Bahar I (2019) Handbook of experimental pharmacology. Epub 2019/06/16. doi: 10.1007/164_2019_239. PubMed PMID: 31201557.
Applications of the Microphysiology Systems Database for Experimental ADME-Tox and Disease Models. Schurdak M, Vernetti L, Bergenthal L, Wolter QK, Shun TY, Karcher S, Taylor DL and Gough A (2019) bioRxiv:776500. doi: 10.1101/776500.