Tissue Chip Testing Center

The UPDDI is one of the three Tissue Chip Testing Centers (TCTCs) funded by the National Center for Advancing Translational Sciences (NCATS) to validate tissue chips for drug efficacy and toxicity testing.  As the Microphysiology Systems Data Center we are supporting the informatics needs of this initiative by extending our Microphysiology Systems Database (MPS-Db) to capture and analyze experimental data generated on diverse organ models by Dr. Ivan Rusyn’s team at Texas A&M University and Dr. Murat Cirit’s team at MIT.  The MPS-Db captures and organizes all experimental parameters regarding cell types, drugs tested in the devices so that they may be easily accessed, tracked and used to characterize drug responses in the experimental model.  We are developing and implementing tools to evaluate the performance of the tissue chips using known drugs, including their reproducibility and concordance with clinical data, and to construct computational models to predict human organ efficacy and toxicity of new compounds. The Center’s approach exploits University of Pittsburgh’s strengths in drug discovery science, informatics, and database development.