Positions Available

Post-Doctoral Position in Human Liver Microphysiology Systems (MPS)

In the laboratory of D. Lansing Taylor, Ph.D., Director, University of Pittsburgh Drug Discovery Institute (UPDDI) Distinguished Professor and Allegheny Foundation Professor of Computational and Systems Biology

Job Description

The UPDDI is searching for a Postdoctoral Fellow to apply our vascularized human liver microphysiology system (vLAMPS) of non-alcoholic fatty liver disease (NAFLD) using both primary human cells and iPSC-derived cells for application in a patient cohort “preclinical trial” project. Great talent in cell-based experimentation, knowledge of liver physiology and the use of imaging systems is required. This is an excellent opportunity to get involved in a high profile collaboration to apply MPS models of disease and toxicology in a preclinical trial format working with engineers, cell and molecular biologists, computational biologists, pharmacologists and clinician-scientists. The goal is to identify optimal patients to be enrolled in clinical trials with drugs in development.

Start Date: Fall 2020


Experience and Training

• Ph.D in physiology, cell biology, biophysics, biomedical engineering, or related field

Strong cell-based research experience

• Experience in liver cell and organ physiology, cell and molecular biology a plus

• Experience with primary human cells and iPSCs a plus.

Position Responsibilities

• Optimize the application of the human, 4 cell-type vLAMPS model of NAFLD over one month period with various drug treatments and interpret the biochemical, biosensor, molecular and pathology read-outs.

• Collaborate with the liver microphysiology systems team and clinician-scientists at Pitt

• Plan and execute experiments, analyze and present results in seminars and publications

Applicants are invited to send their CV, and names of two references (or reference letters) to:

Connor Wege

Institute Administrator


or mail to:

Connor Wege, Institute Administrator

Drug Discovery Institute

University of Pittsburgh School of Medicine

W955 Biomedical Science Tower

200 Lothrop Street

Pittsburgh, PA 15261, USA

The University of Pittsburgh is an Affirmative Action, Equal Opportunity Employer