Mcm2-7 Replicative Helicase

Aberrant DNA replication is a hallmark of cancer, however disease-specific inhibitors for this process are largely unavailable. Many chemotherapeutic agents target DNA replication but have deleterious side effects. As blocking DNA replication during elongation may itself cause genome instability, developing inhibitors to specifically block replication before it starts (during initiation) is an attractive approach. The Schwacha laboratory has identified the Mcm2-7 replicative helicase as a novel cancer-specific potential target in DNA replication initiation.