Publications:
Vinny Negi1, Dillon Gavlock2, Mark T. Miedel2, Jeong Kyung Lee1, Tongying Shun2, Albert Gough2, Lawrence Vernetti2, Andrew M. Stern2, D. Lansing Taylor2, Vijay K. Yechoor1. Modeling mechanisms underlying differential inflammatory responses to COVID-19 in Type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system. Lab on a Chip, 2023, DOI: 10.1039/D3LC00285C
Lefever DE, Miedel MT, Pei F, DiStefano JK, Debiasio R, Shun TY, Saydmohammed M, Chikina M, Vernetti LA, Soto-Gutierrez A, Monga SP, Bataller R, Behari J, Yechoor VK, Bahar I, Gough A, Stern AM, Taylor DL. A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies. Metabolites. 2022;12(6). doi: 10.3390/metabo12060528. PubMed PMID: 35736460; PMCID: PMC9227696.
Beaudoin JJ, Lara Clemens L, Miedel MT, Gough A, Zaidi F, Ramamoorthy P, Wong K, Sarangarajan R, Battista C, Shoda LKM, Siler SQ, Taylor DL, Howell BA, Vernetti LA, Yang K. The combination of a human biomimetic liver microphysiology system with BIOLGXsym, a quantitative toxicology (QST) modeling platform for macromolecules, provides mechanistic understanding of Tocilizumab- and GGF2-induced liver injury. IJMS, accepted May, 2023.
Florentino RM, Morita K, Haep N, Motomura T, Diaz-Aragon R, Faccioli LAP, Collin de l’Hortet A, Cetin Z, Frau C, Vernetti L, Amler AK, Thomas A, Lam T, Kloke L, Takeishi K, Taylor DL, Fox IJ, Soto-Gutierrez A. Biofabrication of synthetic human liver tissue with advanced programmable functions. iScience. 2022;25(12):105503. PubMed PMID: 36404924; PMCID: PMC9672940.
Przepiorski A, Vanichapol T, Espiritu EB, Crunk AE, Parasky E, McDaniels MD, Emlet DR, Salisbury R, Happ CL, Vernetti LA, MacDonald ML, Kellum JA, Kleyman TR, Baty CJ, Davidson AJ, Hukriede NA. Modeling oxidative injury response in human kidney organoids. Stem Cell Res Ther. 2022 Feb 21;13(1):76. doi: 10.1186/s13287-022-02752-z. PMID: 35189973; PMCID: PMC8862571.
Hrizo SL, Eicher SL, Myers TD, McGrath I, Wodrich APK, Venkatesh H, Manjooran D, Swoger S, Gagnon K, Bruskin M, Lebedev MV, Zheng S, Vitantonio A, Kim S, Lamb ZJ, Vogt A, Ruzhnikov MRZ, Palladino MJ. Identification of protein quality control regulators using a Drosophila model of TPI deficiency. Neurobiol Dis. 2021;152:105299. PMID: 33600953; PMCID: PMC7993632.
Vogt A., Eicher S., Myers T., Hrizo S., Vollmer L., A, Meyer EM., and Palladino MJ. A high content screening assay for small molecules that stabilize mutant triose phosphate isomerase (TPI) as treatments for TPI-deficiency. SLAS Discov. 2021 Jun24, Online ahead of print. PMID: 34167376; PMCID: NIHMS1704229.
Chen FY, Shi QY, Pei F, Vogt A, Porritt RA, Garcia G, Gomez AC, Cheng MH, Schurdak ME, Liu B, Chan SY, Arumugaswami V, Stern AM, Taylor DL, Arditi M, Bahar I. A systems-level study reveals host-targeted repurposable drugs against SARS-CoV-2 infection. Molecular Systems Biology. 2021 June;17(8). doi: ARTN e1023910.15252/msb.202110239. PubMed PMID: 34339582.
Albert Gough, Alejandro Soto-Gutierrez, Lawrence Vernetti, Mo R. Ebrahimkhani, Andrew M. Stern, D. Lansing Taylor. Human biomimetic liver microphysiology systems in drug development and precision medicine. Nature Reviews Gastroenterol Hepatol, 2021;18(4):252-68.
Courtney Sakolish; Yu-Syuan Luo; Alan Valdiviezo; Lawrence A. Vernetti; Ivan Rusyn. Prediction of Hepatic Drug Clearance with a Human Microfluidic Four-Cell Liver Acinus MicroPhysiology System. Toxicology. 2021 Nov;463:152954.
Liu X, Feng B, Vats A, Tang H, Seibel W, Swaroop M, Tawa G, Zheng W, Byrne L, Schurdak M, Chen Y. Pharmacological clearance of misfolded rhodopsin for the treatment of RHO-associated retinitis pigmentosa. PubMed PMID: 32536017. FASEB J. 2020 August; 34(8): 10146–10167. doi:10.1096/fj.202000282R.