Systems-level approaches to discover host-targeted repurposable drugs against SARS-CoV-2 infection
The UPDDI is participating in a COVID19-related project aimed at discovering potential new treatments for the disease through a collaborative effort by research groups at the University of Pittsburgh Department of Computational and Systems Biology, the University of California, Los Angeles (UCLA), and Cedars Sinai Hospital. Through a series of sophisticated mathematical and artificial intelligence-based methods, the team identified a number of potential candidates that were tested in the laboratory for inhibition of SARS-CoV-2 infection and cellular entry. The most promising candidates are currently being considered for further development into potential COVID19 therapies.
Chen F, Shi Q, Pei F, Vogt A, Porritt RA, Garcia G, Jr., Gomez AC, Cheng MH, Schurdak ME, Liu B, Chan SY, Arumugaswami V, Stern AM, Taylor DL, Arditi M, Bahar I. A systems-level study reveals host-targeted repurposable drugs against SARS-CoV-2 infection. Mol Syst Biol. 2021;17(8):e10239. PubMed PMID: 34339582. (open access) http://dx.doi.org/10.15252/msb.202110239