Zebrafish Discovery

The zebrafish embryo is an ideal animal system for in vivo HCS. We apply HCS to identify small molecules that modulate pathways in zebrafish embryos. The 1-day old embryo is approximately 1mm in diameter and can be easily arrayed into 96-well plates for screening. During the first day of development, embryos are transparent with most of the major organs present, thus enabling visualization of tissue formation during embryogenesis, and organ specific measurements.