The Drug Discovery Institute has received a Shared Instrumentation Grant (S10) of over one million dollars to purchase a new state-of-the-art Opera Phenix High Content Imaging System. The instrument will support drug discovery and advanced biomedical research requiring HCS in the Pittsburgh region, as exemplified by projects that span a wide range of applications, including: genetically modified cellular models; zebrafish chemical screening; human microphysiology systems; and microvascular organoids from pluripotent stem cells. The range of diseases is likewise broad and reflects the diversity of biomedical research in the Pittsburgh area, including: NAFLD, Type 2 Diabetes, Liver Cancer, Neurodegenerative diseases, and Metastatic Cancer, as well as other initiatives across the institution.